Povidone

polyvinyl pyrrolidone(PVP K)

CAS:9003-39-8

PVP K15; PVP K17; PVP K25; PVP K30; PVP K90

Molecular formula: (C6H9NO)n

Average molecular weight: 8000-700000

Stability: Stable under normal temperature and pressure

Solubility: Very soluble in water and halogenated hydrocarbon solvents, alcohols, amines, nitroalkanes and low molecular weight fatty acids, insoluble in acetone, ether, turpentine, aliphatic hydrocarbons and alicyclic hydrocarbons Solvent. It can be compatible with most inorganic acid salts and various resins.

Characteristics: It has a hydrophilic, easily flowable white or nearly white powder with a slight odor.

As a synthetic water-soluble polymer compound, PVP has the general properties of water-soluble polymer compounds, colloidal protection, film formation, cohesiveness, hygroscopicity, solubilization or coagulation, but it is the most distinctive and thus People pay attention to its excellent solubility and physiological compatibility. In synthetic polymers, like PVP, it is soluble in water and soluble in most organic solvents. It is very low in toxicity and physiologically compatible, especially in medicine, food and cosmetics.And other areas closely related to people's health.


  • Medicine & Health

PVP has excellent physiological inertia, does not participate in human metabolism, and has excellent biocompatibility, and does not form any irritation to skin, mucous membranes, eyes and the like. Pharmaceutical grade PVP is one of the three major medicinal excipients advocated by the international community. It can be used as a binder for tablets and granules, as a co-solvent for injections, as a glidant for capsules, as an antidote for eye drops, as a deterrent, and for lubrication. Agents and coating film formers, dispersing agents for liquid preparations and stabilizers for enzymes and heat sensitive drugs can also be used as cryopreservatives. Used in contact lenses to increase their hydrophilicity and lubricity. PVP K30 has been officially listed with the approval of the National Pharmaceutical Administration. The company also supplies Povidone K30 with approval number. 

From a biological point of view, the molecular structure of PVP is similar to that of a simple protein model, even its water-soluble ability to bind certain small molecules and ammonium sulfate, which is a precipitant for certain proteins. Properties such as precipitation of trichloroacetic acid, tannic acid and phenols are also compatible with proteins. So that PVP is widely used as an excipient for pharmaceutical preparations, the specific application is as follows: 1 as a binder for the preparation 2 coprecipitant 3 as a cosolvent in the injection or a crystallization inhibitor 4 coating or film former 5 controlled release of slow-release and sustained-release drugs can prolong the action time of the drug. 6 artificial vitreous and corneal 7 surgical banding 8PVP iodine disinfectant. In addition, PVP can also be used as a coloring agent and X-ray contrast agent; it can be used in various dosage forms such as tablets, granules and water, and has the functions of detoxification, hemostasis, increasing dissolution concentration, preventing peritoneal adhesion, and promoting blood sedimentation.

  • food processing

PVP itself does not cause cancer, has good food safety, can form complexes with specific polyphenol compounds (such as tannins), and is mainly used as food clarifying agent and stabilizer for beer, juice, wine, etc. in food processing. PVP can form complexes with specific polyphenolic compounds such as tannins, which provide clarification and anti-coagulation in fruit juice beverages. For example, Buschke H et al. added 0.01% ~ 0.02% soluble PVP in the fermenter to effectively reduce the freezing point. The use of PVP in the production of wine and vinegar can also play the same role. Cross-linked PVP is widely used in beer and tea beverages. The polyphenols in beer can combine with the protein in beer to form a tannin macromolecule, which will seriously affect the flavor of beer and shorten its shelf life. Cross-linked polyvinylpyrrolidone (PVPP) can be combined with tannic acid and anthocyanins in beer to clarify beer, improve beer storage stability and extend shelf life. In the tea beverage, the use of PVPP can appropriately reduce the content of tea polyphenols, and PVPP does not remain in the tea beverage, and can be reused, thereby greatly reducing the cost. 

  • Daily cosmetics

In the consumption structure of PVP, the cosmetics industry in developed countries accounts for 30% to 50%, and China accounts for 70% to 80%. Since PVP has extremely low toxicity and physiological inertia, it has no irritation to the skin and eyes, and has a long-term use record in the medical field, so it is safe for use in cosmetics and the like. In daily cosmetics, PVP and copolymer have good dispersibility and film formability. PVP has a protective colloid effect in the emulsion. It can be used in fat and non-fat pastes, as a setting liquid, hair spray and rubber. A styling agent for silk, an opacifier for hair conditioners, a foam stabilizer for shampoos, a wave styling agent, and a dispersing agent and an affinity agent in hair dyes. Add PVP to cream, sunscreen and depilatory to enhance moisturizing and lubricating effects.

  • Detergent

PVP has anti-soil re-precipitation performance, can be used to prepare transparent liquid or heavy dirt detergent. Adding PVP to detergent has good anti-color conversion effect, and can enhance the cleaning ability. It can prevent synthetic detergent when washing fabric. Skin irritation, especially for synthetic fibers, is more pronounced than carboxymethyl cellulose (CMC) detergents. PVP can be formulated with borax as an active ingredient in phenol-containing disinfectant formulations. The detergent compounded with PVP and hydrogen peroxide solid has the function of bleaching and killing bacteria.

  • Textile

PVP has a good affinity with many organic dyes. It can be combined with hydrophobic synthetic fibers such as polyacrylonitrile, ester, nylon and fibrous materials to improve dyeing power and hydrophilicity. Kirsh Y E et al. reported that after the graft copolymerization of PVP and nylon, the fabric produced improved wet wrinkle resistance and moisture resistance.

  • Paints and pigments

PVP coated paints and coatings are transparent to the film without affecting the original color, improving the gloss and dispersibility of the paint and pigment, improving the thermal stability and improving the dispersibility of the ink and ink.

  • Polymer surfactant

As a polymeric surfactant, polyvinylpyrrolidone can be used as a dispersing agent, emulsifier, thickener, leveling agent, particle size regulator, anti-redeposition agent, coagulant, cosolvent and washing in different dispersion systems. Agent.

  • Catalyst preparation

As the active agent, the colloidal particles are used for the preparation process of the core-shell catalyst.

  • Other aspects

PVP can be used as a gelling agent for tertiary oil recovery to improve the oil recovery rate of oil fields. The additive as a photosensitive material contributes to lowering the degree of latex and enhancing the coverage of the developed image. Used as a thickener, dispersion stabilizer, and adhesion modifier in polymer polymerization. Used as a dispersant in the paper industry as a cocatalyst in the propylene amine gasification reaction. The application of PVP in separation membranes, photocurable resins, laser discs, drag coatings, building materials, steel making and electroplating is also on the rise.