PVP has excellent physiological inertia, does not participate in human metabolism, and has excellent biocompatibility, and does not form any irritation to skin, mucous membranes, eyes and the like. Pharmaceutical grade PVP is one of the three major medicinal excipients advocated by the international community. It can be used as a binder for tablets and granules, as a co-solvent for injections, as a glidant for capsules, as an antidote for eye drops, as a deterrent, and for lubrication. Agents and coating film formers, dispersing agents for liquid preparations and stabilizers for enzymes and heat sensitive drugs can also be used as cryopreservatives. Used in contact lenses to increase their hydrophilicity and lubricity.
From a biological point of view, the molecular structure of PVP is similar to that of a simple protein model, even its water-soluble ability to bind certain small molecules and ammonium sulfate, which is a precipitant for certain proteins. Properties such as precipitation of trichloroacetic acid, tannic acid and phenols are also compatible with proteins. So that PVP is widely used as an excipient for pharmaceutical preparations, the specific application is as follows:
- As a binder for the preparation.
- As a cosolvent in the injection or a crystallization inhibitor.
- Coating or film former.
- Controlled release of slow-release and sustained-release drugs can prolong the action time of the drug.
- Artificial vitreous and corneal.
- Surgical banding.
- PVP iodine disinfectant.
In addition, PVP can also be used as a coloring agent and X-ray contrast agent; it can be used in various dosage forms such as tablets, granules and water, and has the functions of detoxification, hemostasis, increasing dissolution concentration, preventing peritoneal adhesion, and promoting blood sedimentation.